Intermediates
Hermes develops and manufactures a wide range of products in our intermediate division. As one of our core values is to manufactures every API we make from basic to ensure lack of dependence on any outside vendor. Our intermediate list is as follows:
| End Use | Product | CAS Number |
|---|---|---|
| Acotiamide Hydrochloride | 2,4,5-Trimethoxybenzoic acid | 490-64-2 |
| 2-Aminothiazole-4-carboxylic acid ethyl ester | 5398-36-7 | |
| Ambroxol Hydrochloride | 2-Amino-3,5-Dibromo Benzaldehyde | 50910-55-9 |
| Trans-4-Amino Cyclohexanol | 27489-62-9 | |
| Amisulpride | (N)-Ethyl-2-Aminomethyl pyrrolidine | 26116-12-1 |
| 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic acid | 71675-87-1 | |
| Apixaban | Ethyl-2-chloroacetoacetate | 609-15-4 |
| 1-(4-aminophenyl)-5,6-dihydro-3-morpholinopyridin-2(1H)-one | 1267610-26-3 | |
| 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one | 545445-44-1 | |
| Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate | 473927-63-8 | |
| Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate | 536759-91-8 | |
| Aripiprazole | Bis(2-chloroethyl) amine hydrochloride | 821-48-7 |
| 1-(2,3-Dichlorophenyl) Piperazine Hydrochloride | 119532-26-2 | |
| 7-Hydroxy-3,4-Dihydro-2(1H)-quinolinone | 22246-18-0 | |
| Biperiden Hydrochloride | 5-Norbornene-2-Carbonitrile (Mixture of Endo/Exo Isomers) | 95-11-4 |
| 5-Acetyl-2-Norbornene (Mixture of Endo/Exo Isomers) | 5063-03-6 | |
| Piperidine Hydrochloride | 6091-44-7 | |
| 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol (Biperiden Base) | 514-65-8 | |
| Bilastine | Piperidine-4-Carboxylic Acid/Isonipecotic Acid | 498-94-2 |
| 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride | 1841081-72-8 | |
| Methyl 2-(4-(2-chloroethyl)phenyl)-2-methylpropanoate | 1181267-33-3 | |
| Bisoprolol Fumarate | 4-Hydroxybenzaldehyde | 123-08-0 |
| 4-Hydroxybenzyl alcohol | 623-05-2 | |
| 2-((4-((2-Isopropoxyethoxy)methyl)phenoxy)methyl)oxirane | 66722-57-4 | |
| Brinzolamide Hydrochloride | 3-Acetyl-2,5-dichlorothiophene | 36157-40-1 |
| 3-(2-Bromoacetyl)-5-chloro-2-thiophene sulfonamide | 160982-11-6 | |
| Bupropion Hydrochloride | 3-Chloropropiophenone | 34841-35-5 |
| 3’-Chloro-2-bromopropiophenone | 34911-51-8 | |
| Carvedilol | 1,3-Cyclohexanedione | 504-02-9 |
| 1,2,3,9-tetrahydro-4H-carbazol-4-one | 15128-52-6 | |
| 4-Hydroxycarbazole | 52602-39-8 | |
| 4-(2,3-Epoxypropoxy)carbazole | 51997-51-4 | |
| 2-(2-Methoxyphenoxy)ethylamine | 1836-62-0 | |
| Cinacalcet Hydrochloride | 3-[3'-(Trifluoromethyl)phenyl) propanol | 78573-45-2 |
| (R)-(+)-1-(1-Naphthyl)ethylamine Hydrochloride | 82572-04-1 | |
| Cinnarizine | Benzhydrol/Diphenylmethanol | 91-01-0 |
| Dabigatran Etexilate Mesylate | Ethyl 3-[2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridine-2-yl)-1H- benzo(d)imidazole-5-carbaxamido]propanoate | 211915-84-3 |
| 3-Chloro-1-phenylpropan-1-one/3-Chloropropiophenone | 936-59-4 | |
| 3-Chloro-1-phenylpropan-1-ol | 18776-12-0 | |
| Darifenacin Hydrobromide | (S)-3-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine-L-Tartrate | 134002-26-9 |
| 2,3-Dihydrobenzofuran-5-acetic acid | 69999-16-2 | |
| 5-(2-bromoethyl)-2,3-dihydrobenzofuran | 127264-14-6 | |
| Deferasirox | 4-Hydrazinobenzoic Acid | 24589-77-3 |
| 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one | 1218-69-5 | |
| Diphenhydramine | Benzhydrol/Diphenylmethanol | 91-01-0 |
| Donepezil Hydrochloride | Ethyl Piperidine-4-Carboxylate/Ethyl Isonipecotate | 1126-09-6 |
| 1-Benzyl-4-Piperidine Carboxaldehyde | 22065-85-6 | |
| 5,6 Dimethoxy-1-Indanone | 2107-69-9 | |
| Dorzolamide Hydrochloride | (6S)-6-Methyl-4-Oxo-5,6-Dihydro-4H-Thieno [2,3-b] Thiopyran-2-Sulfonamide | 1383784-43-7 |
| Thiophene-2-Thiol | 7774-74-5 | |
| Duloxetine Hydrochloride | 3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride | 5424-47-5 |
| 3-(Dimethylamino)-1-(2-thienyl)-1-propanol | 13636-02-7 | |
| (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol | 132335-44-5 | |
| S-(+)-N,N-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate | 132335-47-8 | |
| Ebastine | Benzhydrol/Diphenylmethanol | 91-01-0 |
| Entacapone | 5-Nitrovanillin | 6635-20-7 |
| 3,4-Dihydroxy-5-Nitro Benzaldehyde | 116313-85-0 | |
| N,N-Diethyl-2-Cyano Acetamide | 26391-06-0 | |
| Etoricoxib | Methyl 6-Methyl Nicotinate | 5470-70-2 |
| 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone | 221615-75-4 | |
| 2-Chloro-1,3-bis(dimethylamino)trimethinium hexafluorophosphate | 249561-98-6 | |
| Ezetimibe | (S)-(+)-4-Phenyl-2-oxazolidinone | 99395-88-7 |
| Febuxostat | 4-Hydroxybenzaldehyde | 123-08-0 |
| 4-Hydroxybenzonitrile/4-Cyanophenol | 767-00-0 | |
| Ethyl-2-chloroacetoacetate | 609-15-4 | |
| 4-Hydroxythiobenzamine | 25984-63-8 | |
| Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate | 161797-99-5 | |
| Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate | 161798-01-2 | |
| Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate-methyl-1,3-thiazole-5-carboxylate | 161798-03-4 | |
| Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate-methyl-1,3-thiazole-5-carboxylate | 160844-75-7 | |
| Fenofibrate | 4-Chloro-4’-hydroxybenzophenone | 42019-78-3 |
| Fexofenadine Hydrochloride | Piperidine-4-Carboxylic Acid/Isonipecotic Acid | 498-94-2 |
| Azacyclonol/Diphenyl(piperidin-4-yl)methanol | 115-46-8 | |
| Fluconazole | 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone | 86404-63-9 |
| Glimepiride | 3-ethyl-4-methyl-3-pyrrolin-2-one (EMPO) | 766-36-9 |
| Irbesartan | 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride | 151257-01-1 |
| 4-Bromomethyl-2-cyanobiphenyl | 114772-54-2 | |
| Itopride | 4-Hydroxybenzaldehyde | 123-08-0 |
| 4-Hydroxybenzylamine | 696-60-6 | |
| 3,4-Dimethoxybenzoic Acid/Veratric Acid | 93-07-2 | |
| Itraconazole | 1-4(4-Methoxyphenyl)piperazine | 38212-30-5 |
| 1-(4-Methoxyphenyl)-4-(4-nitrophenyl) piperazine | 74852-61-2 | |
| Bis(2-chloroethyl)amine Hydrochloride | 821-48-7 | |
| Cis-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate (Cis Bromo Benzoate) | 61397-56-6 | |
| Ketoconazole | 1-Acetyl-4-(4-Hydroxyphenyl) Piperazine | 61397-56-6 |
| cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate (Cis Bromo Benzoate) | 61397-56-6 | |
| 2,4 dichloroacetophenone | 2234-16-4 | |
| Bis(2-chloroethyl) amine hydrochloride | 821-48-7 | |
| Ketoprofen | 3-(1-Cyanoethyl) Benzoic Acid | 5537-71-3 |
| 2-(3-Benzoylphenyl)propanenitrile/Ketoprofen Nitrile | 42872-30-0 | |
| Lacosamide | N-(tert-Butoxycarbonyl)-D-serine/Boc-D-Serine | 6368-20-3 |
| (R)-tert-Butyl-1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate | 880468-89-3 | |
| Lamotrigine | 2,3 Dichloro Benzoyl Nitrile | 77668-42-9 |
| Hydrazine Carboximidamide 2-[Cyano (2,3-Dichlorophenyl)] Methane (Schiff Base) | 84689-20-3 | |
| Levosulpiride | (S)-2-(Aminomethyl)-N-ethyl pyrrolidine | 22795-99-9 |
| Methyl 2-methoxy-5-sulfamoylbenzoate | 33045-52-2 | |
| Linagliptin | 8-Bromo-3-methylxanthine | 93703-24-3 |
| 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine | 666816-98-4 | |
| 2-Butyl-1-ol | 764-01-2 | |
| 2-(Chloromethyl)-4-methylquinazoline | 109113-72-6 | |
| (R)-3-(Boc-amino)piperidine | 309956-78-3 | |
| Linezolid | 3-fluoro-4-morpholinyl aniline | 93246-53-8 |
| Losartan Potassium | 2-Butyl-4-Chloro-5-Formylimidazole | 83857-96-9 |
| 4-Bromomethyl-2-cyanobiphenyl | 114772-54-2 | |
| Luliconazole | 2- Chloro-1-(2,4-dichlorophenyl) ethanone/2,2’,4’-Trichloroacetophenone | 4252-78-2 |
| (αS)2,4-dichloro-α-(chloromethyl)-benzene methanol methane sulphonate | 114772-54-2 | |
| 2-(1H-imidazol-1-yl)acetonitrile/1-(Cyanomethyl)imidazole | 98873-55-3 | |
| Miconazole | 2- Chloro-1-(2,4-dichlorophenyl) ethanone/2,2’,4’-Trichloroacetophenone | 4252-78-2 |
| 1-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-yl) Ethanol | 24155-42-8 | |
| Modafinil | Benzhydrol/Diphenylmethanol | 91-01-0 |
| 2-[(Diphenylmethyl)thio] acetamide | 68524-30-1 | |
| Moxifloxacin Hydrochloride | (S,S)-2,8-Diazabicyclo[4,3,0]nonane | 151213-40-0 |
| Nebivolol Hydrochloride | 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid | 99199-60-7 |
| 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran | 99199-90-3 | |
| Olanzapine | 2-Amino-5-methyl-3-thiophenecarbonitrile | 138564-58-6 |
| 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile | 138564-59-7 | |
| 2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride | 138564-60-0 | |
| Ondansetron Hydrochloride | 1,3-Cyclohexanedione | 504-02-9 |
| 1,2,3,9-tetrahydro-4H-carbazol-4-one | 15128-52-6 | |
| 1,2,3,9-tetrahydro-9-methyl-4H-carbazole-4-one | 27387-31-1 | |
| 3-[(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one Hydrochloride | 119812-29-2 | |
| Olmesartan Medoxomil | 4- Chloromethyl-5-Methyl-1,3-Dioxol-2-One | 80841-78-7 |
| 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester | 144689-93-0 | |
| 5-(4'-Bromomethyl-1, 1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole | 124750-51-2 | |
| (5-Methyl-2-oxo-1,3-dioxolen-4yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate/Trityl Olmesartan | 144690-92-6 | |
| Oxybutynin Hydrochloride | α-Phenylcyclohexaneglycolic Acid Methyl Ester | 10399-13-0 |
| Pinaverium Bromide | 4-(2-Chloroethyl)morpholine hydrochloride | 3647-69-6 |
| 2-Bromo-4,5-dimethoxybenzyl bromide | 53207-00-4 | |
| Palonosetron Hydrochloride | 1,2,3,4-Tetrahydro-1-naphthoic acid | 1914-65-4 |
| (S)-(-)-1,2,3,4-Tetrahydro-1-naphthoic acid | 85977-52-2 | |
| (S)-(-)-3-Aminoquinuclidine dihydrochloride | 119904-90-4 | |
| Pregabalin | (±)-3-Carbamoymethyl)-5-methylhexanoic acid | 181289-15-6 |
| (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid | 181289-33-8 | |
| Rasagiline | 1-Indanone | 83-33-0 |
| Rivaroxaban | 4-(4-Aminophenyl)morpholin-3-one | 438056-69-0 |
| (S)-N-Glycidylphthalimide | 161596-47-0 | |
| 5-Chlorothiophene-2-Carboxylic Acid | 24065-33-6 | |
| Salbutamol Sulphate | 1-(4’-Hydroxy-3’-hydroxymethylphenyl)-2-(benzyl-tert-butylamino)ethanol (O-Benzyl Salbutamol) | 24085-03-8 |
| Silodosin | 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate | 239463-85-5 |
| 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate | 160969-03-9 | |
| Sitagliptin Phosphate | 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride | 762240-92-6 |
| Solifenacin Succinate | (S)-1-Phenyl-1,2,3,4-Tetrahydro Isoquinoline | 118864-75-8 |
| Ethyl Piperidine-4-Carboxylate/Ethyl Isonipecotate | 1126-09-6 | |
| 3-Quinuclidinol | 1619-34-7 | |
| (R)-(-)-3-Quinuclidinol | 25333-42-0 | |
| Tadalafil | D-Tryptophan Methyl Ester Hydrochloride | 14907-27-8 |
| Tamsulosin Hydrochloride | R-(-)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide | 112101-81-2 |
| 2-(2-Ethoxyphenoxy)ethyl bromide | 3259-03-8 | |
| Tapentadol Hydrochloride | 3’-Methoxypropiophenone | 37951-49-8 |
| Telmisartan | Methyl 4-amino-3-methylbenzoate | 18595-14-7 |
| Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate | 152628-01-8 | |
| 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid | 152628-03-0 | |
| 2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole | 152628-02-9 | |
| 4’-[(1,4’-Dimethyl-2’-propyl[2,6’-bi-1H-benzimidazol]-1’-yl)methyl]-[1,1’-biphenyl]-2-carbonitrile | 144702-27-2 | |
| Terbutaline Sulphate | 3,5-Dihydroxybenzoic acid | 99-10-5 |
| 3,5-Dibenzyloxy Acetophenone | 28924-21-2 | |
| Tioconazole | 2- Chloro-1-(2,4-dichlorophenyl) ethanone/2,2’,4’-Trichloroacetophenone | 4252-78-2 |
| 1-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-yl) Ethanol | 24155-42-8 | |
| 2-Chloro-3-Methyl-Thiophene | 14345-97-2 | |
| Topiramate | 2,3:4,5-Bis-o-(1-methylethylidene)-β-D-fructopyranose | 20880-92-6 |
| Valsartan | L-Valine Methyl Ester Hydrochloride | 6306-52-1 |
| 4-Bromomethyl-2-cyanobiphenyl | 114772-54-2 | |
| N-[(2’-Cyanobiphenyl-4-yl)methyl]-(L)-Valine Methyl Ester Hydrochloride | 482577-59-3 | |
| Venlafaxine Hydrochloride | 1-[2-Amino-1-(4-methoxyphenyl)ethyl] cyclohexanol | 93413-77-5 |
| 1-[2-Cyano-1-(4-methoxyphenyl)methyl cyclohexanol | 93413-76-4 | |
| Vilazodone Hydrochloride | Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate | 163521-20-8 |
| 3-(4-Chlorobutyl) Indole-5-Carbonitrile | 143612-79-7 | |
| Voriconazole | 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone | 86404-63-9 |
| Ziprasidone Hydrochloride | 3-(1-Piperazinyl)-1,2-Benzisothiazole hydrochloride | 87691-88-1 |
| 6-Chloro-5-(2-chloroethyl)-2-oxindole | 56341-37-8 |
Note: The above products will NOT be supplied to countries where they could conflict with existing patents. However, the final responsibility lies exclusively with the buyer